The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

Abstract The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction.After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression of the p75NTR pan-neurotrophin receptor.Even though p75NTR targeting has emerged as a promising therapeutic strategy t

read more



Development of one control and one tumor-specific induced pluripotent stem cell line from laryngeal carcinoma patient

Skin Inline - Skates - Womens fibroblasts and tumor fibroblasts were extracted from a 64-year old male patient clinically diagnosed with laryngeal carcinoma.Control and tumor specific induced pluripotent stem cells were reprogrammed with 5 reprogramming factors, Klf-4, c-Myc, Oct-4, Sox-2, and Lin-28, using the messenger RNA reprogramming system.Th

read more